Solute excretion, metabolism, and cardio‐renoprotection via two distinct mechanisms revolutionize clinical outcomes

Registries revolutionize care and outcomes.

No one could believe I’d had two knees replaced”, says 61-year-old Jacquelyn Winn. In 2010, Winn traveled more than 2,800 miles across Japan to fulfill her dream of seeing Mt. Fuji. “I kept up with the activities and didn’t need any extra breaks. We walked an average of 10 miles a day.” The decision to undergo joint replacement surgery is difficult and worrisome for patients like Winn. She suff...

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms.

The p53 protein maintains genomic integrity through its ability to induce cell cycle arrest or apoptosis in response to various forms of stress. Substantial regulation of p53 activity occurs at the level of protein stability, largely determined by the activity of the Mdm2 protein. Mdm2 targets both p53 and itself for ubiquitylation and subsequent proteasomal degradation by acting as an ubiquiti...

Perceptual learning shapes multisensory causal inference via two distinct mechanisms

To accurately represent the environment, our brains must integrate sensory signals from a common source while segregating those from independent sources. A reasonable strategy for performing this task is to restrict integration to cues that coincide in space and time. However, because multisensory signals are subject to differential transmission and processing delays, the brain must retain a de...

Mechanisms of Drug Interactions I Absorption, Metabolism, and Excretion

Cutting Edge: Two Distinct Mechanisms